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  • Title: Anti-influenza diarylheptanoids from the bark of Alnus japonica.
    Author: Tung NH, Kwon HJ, Kim JH, Ra JC, Ding Y, Kim JA, Kim YH.
    Journal: Bioorg Med Chem Lett; 2010 Feb 01; 20(3):1000-3. PubMed ID: 20045319.
    Abstract:
    This study to investigate anti-influenza components from the bark of Alnus japonica resulted in the isolation of two rare acylated diarylheptanoids, named oregonoyl A (5) and oregonoyl B (6), along with nine known compounds (1-4 and 7-11). Their structures were elucidated on the basis of extensive spectroscopic and chemical methods. Antiviral testing of compounds 1-11 against KBNP-0028 (H9N2) avian influenza virus showed that platyphyllone (10) was strongly active, and platyphyllonol-5-xylopyranoside (9) was moderately active against KBNP-0028 as compared with the positive control, zanamivir, respectively.
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