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  • Title: Novel therapy for transthyretin-related ocular amyloidosis: a pilot study of retinal laser photocoagulation.
    Author: Kawaji T, Ando Y, Hara R, Tanihara H.
    Journal: Ophthalmology; 2010 Mar; 117(3):552-5. PubMed ID: 20045573.
    Abstract:
    OBJECTIVE: The occurrence of ocular complications associated with transthyretin-related familial amyloidotic polyneuropathy increases with time, even after liver transplantation, which leads to a halt in the progression of systemic neurologic complications. This study investigated a new strategy to prevent ocular involvements. DESIGN: Two interventional case reports. PARTICIPANTS: Two patients with familial amyloidotic polyneuropathy who had progressive ocular manifestations. METHODS: We used panretinal laser photocoagulation, which damages the retinal pigment epithelium, the main location for synthesis of amyloidogenic transthyretin in ocular tissues, to treat 1 eye of each patient. After laser photocoagulation, we performed general ophthalmic examinations every 3 months for 3 years. MAIN OUTCOME MEASURES: Fundus photography, visual acuity, and intraocular pressure. RESULTS: Panretinal laser photocoagulation clearly prevented progression of amyloid deposition in the vitreous and on the retinal surface in both cases during 3 years of follow-up. No serious complications occurred. CONCLUSIONS: Panretinal laser photocoagulation is a safe and well-known procedure that offers a new treatment option to mitigate ocular manifestations in patients with transthyretin-related familial amyloidotic polyneuropathy.
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