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  • Title: Radiosynthesis and micro-SPECT imaging of 99mTc-dendrimer poly(amido)-amine folic acid conjugate.
    Author: Zhang Y, Sun Y, Xu X, Zhu H, Huang L, Zhang X, Qi Y, Shen YM.
    Journal: Bioorg Med Chem Lett; 2010 Feb 01; 20(3):927-31. PubMed ID: 20045643.
    Abstract:
    Acetylated (Ac) dendrimer poly(amido)-amine (PAMAM) generation 5 (G5) reacted with folic acid (FA), followed by reacting with 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetria minepentaacetic acid (1B4M DTPA) to form the conjugate of Ac-G5-FA-1B4M DTPA which was further radiolabeled with (99m)Tc. The radiochemical yield is up to 98.9% with excellent in vitro/in vivo stability, rapid blood clearance and certain tumor accumulation which was further confirmed by micro-SPECT imaging study.
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