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  • Title: Ongoing remission after intensive ALL-type chemotherapy in pediatric intestinal T-cell lymphoma.
    Author: Friedrich C, Schrum J, Chott A, Janka-Schaub G, Kabisch H.
    Journal: Pediatr Blood Cancer; 2010 Apr; 54(4):610-2. PubMed ID: 20049930.
    Abstract:
    A rare case of primary intestinal T-cell lymphoma (ITL) of an 8-year-old boy is reported. Medium- to large-sized tumor cells were betaF1+, CD3+, CD8+. TIA-1+, but CD4-, CD5-, CD30-, CD56-, CD20-, CD79a-, TdT-, consistent with an intraepithelial lymphocyte (IEL) origin. They showed monoclonal rearrangement of the T-cell receptor gamma-chain and no evidence of EBV infection. No clinical, histologic, laboratory, or genetic evidence of celiac disease was detected. In adults, ITL is often associated with enteropathy and has a very poor outcome. Our patient remains in first remission 30 months after finishing the acute lymphoblastic leukemia protocol COALL-07-03 high risk standard.
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