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  • Title: Naptumomab estafenatox: a new immunoconjugate.
    Author: Robinson MK, Alpaugh RK, Borghaei H.
    Journal: Expert Opin Biol Ther; 2010 Feb; 10(2):273-9. PubMed ID: 20053143.
    Abstract:
    IMPORTANCE OF THE FIELD: New agents that specifically engage the immune system are being tested in a variety of malignancies. This review provides an overview of naptumomab, an immunotoxin, with encouraging clinical activity in Phase I trials. AREAS COVERED IN THIS REVIEW: This review examines the preclinical and the published clinical data with regards to naptumomab. WHAT THE READER WILL GAIN: This review provides the reader with an understanding of the mechanism of action, immunology, pharmacokinetics and clinical activity of this agent. TAKE HOME MESSAGE: Naptumomab has a unique mechanism of action and appears to be an active agent in the treatment of refractory solid tumors such as renal cell carcinoma.
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