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  • Title: Immune response among patients exposed to molds.
    Author: Edmondson DA, Barrios CS, Brasel TL, Straus DC, Kurup VP, Fink JN.
    Journal: Int J Mol Sci; 2009 Dec 21; 10(12):5471-84. PubMed ID: 20054481.
    Abstract:
    Macrocyclic trichothecenes, mycotoxins produced by Stachybotrys chartarum, have been implicated in adverse reactions in individuals exposed to mold-contaminated environments. Cellular and humoral immune responses and the presence of trichothecenes were evaluated in patients with mold-related health complaints. Patients underwent history, physical examination, skin prick/puncture tests with mold extracts, immunological evaluations and their sera were analyzed for trichothecenes. T-cell proliferation, macrocyclic trichothecenes, and mold specific IgG and IgA levels were not significantly different than controls; however 70% of the patients had positive skin tests to molds. Thus, IgE mediated or other non-immune mechanisms could be the cause of their symptoms.
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