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  • Title: [Effect of dexmedetomidine on anesthetic requirements in cardiovascular surgery].
    Author: Kanda H, Kunisawa T, Kurosawa A, Nagashima M, Suzuki A, Takahata O, Iwasaki H.
    Journal: Masui; 2009 Dec; 58(12):1496-500. PubMed ID: 20055193.
    Abstract:
    BACKGROUND: An anesthetic-sparing effect of dexmedetomidine has been shown in several studies. We investigated the effect of dexmedetomidine on anesthetic requirements in 24 patients undergoing cardiovascular surgery. METHODS: Patients were randomly divided into two groups in which continuous infusion of dexmedetomidine was started before induction of anesthesia (DEX group, n = 12) or when closing the sternum (control group, n = 12). Dexmedetomidine was administered intravenously at 0.7 microg x kg(-1) x hr(-1) after a bolus infusion at 6.0 microg x kg(-1) x hr(-1) for 10 min. All patients received total intravenous anesthesia with propofol and fentanyl. RESULTS: Mean effect-site concentration of propofol was significantly lower in the DEX group than in the control group (1.9 +/- 0.3 microg x ml(-1) vs 2.5 +/- 0.8 microg x ml(-1)). Mean effect-site concentration of fentanyl in the DEX group was significantly lower than that in the control group (1.93 +/- 0.41 ng x ml(-1) vs 2.67 +/- 0.70 ng x ml(-1). CONCLUSIONS: The combined use of dexmedetomidine decreases anesthetic requirements in cardiovascular surgery.
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