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  • Title: A colorimetric strategy based on a water-soluble conjugated polymer for sensing pH-driven conformational conversion of DNA i-motif structure.
    Author: Wang L, Liu X, Yang Q, Fan Q, Song S, Fan C, Huang W.
    Journal: Biosens Bioelectron; 2010 Mar 15; 25(7):1838-42. PubMed ID: 20056405.
    Abstract:
    Using a water-soluble conjugated polymer (CP) as a sensing probe, we developed a rapid colorimetric detection strategy for pH-driven conformational conversion of DNA i-motif structure. Two sensing configurations were designed: one used CP only to detect the conversion between i-motif and random-coiled state of a C-rich single-strand DNA, the other used CP and a complementary single-strand DNA to investigate the conversion of duplex to i-motif equilibrium. All the conversions would lead to color change observed directly with naked eyes within a few minutes. The limitation of detection (LOD) is as low as 40 nM. More importantly, reversible conformational conversions by adjusting the pH of the system could also be detected.
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