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  • Title: Serotonin delivery into the ventromedial nucleus of the hypothalamus affects differently feeding pattern and body weight in obese and lean Zucker rats.
    Author: Fetissov SO, Meguid MM.
    Journal: Appetite; 2010 Apr; 54(2):346-53. PubMed ID: 20060864.
    Abstract:
    AIM: To determine if central serotonin (5-HT)-induced satiety is altered in obesity. METHODS: Obese and lean Zucker rats received infusion of 5-HT (5 microg/0.5 microl/h) or saline into the ventromedial nucleus of the hypothalamus (VMN) for 2 weeks. RESULTS: In lean rats, 5-HT decreased body weight (7%) and total food intake (15%) which was due to a decreased meal size during the dark phase. In obese rats, a decrease of food intake was also observed in the dark phase, but it was compensated by an increased food intake during the light phase, resulting in no significant changes of total food intake and body weight. In obese rats, meal number but not meal size was affected by 5-HT delivery. Body fat content was not affected by 5-HT in obese rats, while cessation of 5-HT delivery in lean rats resulted in 13% increase. CONCLUSION: Intra-VMN 5-HT in obese rats did not increase meal-associated satiety as it did in lean rats, but modulated hunger. These results show that the Zucker obese phenotype is characterized by VMN resistance to 5-HT, which may contribute to neurobiological mechanisms of increased meal size and food intake and may diminish anti-obesity effects of serotonergic anorexiants.
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