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  • Title: [Cembrane diterpenes in olibanum].
    Author: Wang F, Li Z, Liu T, Hua H.
    Journal: Zhongguo Zhong Yao Za Zhi; 2009 Oct; 34(19):2477-80. PubMed ID: 20067017.
    Abstract:
    OBJECTIVE: To study the constituents in the chloroform extract of olibanum and their antitumor activities. METHOD: The compounds were isolated by chromatographic methods and their structures were identified on the basis of spectroscopic methods and X-ray diffraction. The antiproliferative effect of the compounds in human leukemia HL-60 cells was tested by viable cell counting. RESULT: Four cembrane diterpenes were isolated and identified as incensole-oxide (1), acetyl incensole-oxide (2), incensole (3), and acetyl incensole (4). CONCLUSION: Compounds 2 and 4 were isolated from the genus Boswellia for the first time. Compound 4 showed growth inhibitory effect against human leukemia HL-60 cell lines with IG50 value of (16.3 +/- 3.4) micromol x L(-1).
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