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  • Title: In vivo endoscopic multi-beam optical coherence tomography.
    Author: Standish BA, Lee KK, Mariampillai A, Munce NR, Leung MK, Yang VX, Vitkin IA.
    Journal: Phys Med Biol; 2010 Feb 07; 55(3):615-22. PubMed ID: 20071753.
    Abstract:
    A multichannel optical coherence tomography (multi-beam OCT) system and an in vivo endoscopic imaging probe were developed using a swept-source OCT system. The distal optics were micro-machined to produce a high numerical aperture, multi-focus fibre optic array. This combination resulted in a transverse design resolution of <10 microm full width half maximum (FWHM) throughout the entire imaging range, while also increasing the signal intensity within the focus of the individual channels. The system was used in a pre-clinical rabbit study to acquire in vivo structural images of the colon and ex vivo images of the oesophagus and trachea. A good correlation between the structural multi-beam OCT images and H&E histology was achieved, demonstrating the feasibility of this high-resolution system and its potential for in vivo human endoscopic imaging.
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