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  • Title: [Evaluation of hematologic side effects of anti-infective therapy: agranulocytosis caused by beta-lactam antibiotics, vancomycin and amodiaquine].
    Author: Eich G, Neftel KA.
    Journal: Infection; 1991; 19 Suppl 1():S33-7. PubMed ID: 2007513.
    Abstract:
    Side effects in general and in particular to antiinfective therapy are obviously hardly predictable and a causal relationship is seldom firmly established. The handling of untoward reactions may be improved if a subpopulation which can be identified is at particular risk for a given reaction. A clear assessment of dose and time dependency of untoward reactions is important in this context. Agranulocytosis seen with (i) beta-Lactam-antibiotics, (ii) vancomycin and (iii) amodiaquine can exemplify how simultaneous investigations of epidemiological and experimental aspects lead to identification of a subpopulation at risk.
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