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  • Title: Quantitation of oxycodone in blood and urine using gas chromatography-mass spectrometry (GC-MS).
    Author: Goldberger BA, Chronister CW, Merves ML.
    Journal: Methods Mol Biol; 2010; 603():453-60. PubMed ID: 20077097.
    Abstract:
    Oxycodone is a semisynthetic opioid analgesic used in pain management. In the following method, gas chromatography-mass spectrometry (GC-MS) is used to determine the presence and concentration of the drug in blood and urine. The specimens are fortified with deuterated internal standard and a five-point calibration curve is constructed. Specimens are extracted using mixed-mode solid phase extraction and derivatized with N,O-bis(trimethylsilyl)trifluoroacetamide (BSTFA) producing trimethylsilyl derivatives. The final extracts are then analyzed using selected ion monitoring GC-MS.
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