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  • Title: Enantioselective total synthesis of (+)-conicol via cascade three-component organocatalysis.
    Author: Hong BC, Kotame P, Tsai CW, Liao JH.
    Journal: Org Lett; 2010 Feb 19; 12(4):776-9. PubMed ID: 20078081.
    Abstract:
    The first asymmetric total synthesis of (+)-conicol has been achieved via a key step reaction involving the organocatalytic domino oxa-Michael-Michael-Michael-aldol condensation of 2-((E)-2-nitrovinyl)benzene-1,4-diol and alpha,beta-unsaturated aldehydes. Structures of the three-component domino reaction adducts, 20 and 21, including their absolute configurations, were confirmed unambiguously by X-ray analysis. Through this work, the absolute configuration of (+)-conicol was thereby elucidated.
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