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  • Title: Effect of anaesthetics on the release of beta-endorphin-immunoreactivity in rat plasma.
    Author: Ramirez-Gonzalez MD, Barna I, Wiegant VM, de Jong W.
    Journal: Life Sci; 1991; 48(14):1371-7. PubMed ID: 2008154.
    Abstract:
    Analgesia and anaesthesia produced by fentanyl, urethane and ether, but not pentobarbital, occurred concomitantly with an increase in the concentration of plasma beta-endorphin like immunoreactivity (BEIR), probably of pituitary origin. This increase was not associated with significant changes in pituitary or brainstem beta-endorphin content. Pretreatment with naloxone caused a reduction in plasma BEIR increase following Hypnorm, ether and urethane; and in the analgesia following Hypnorm and urethane. Pentobarbital, alone or in combination with naloxone, did not increase the concentration of plasma beta-endorphin. These results may indicate participation of endogenous opioids in the mechanism of action of urethane.
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