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  • Title: Uridine-cytidine kinase. III. Competition between uridine and cytidine for a single enzyme.
    Author: Liacouras AS, Anderson EP.
    Journal: Mol Cell Biochem; 1977 Oct 07; 17(3):141-6. PubMed ID: 200838.
    Abstract:
    The combined phosphorylation of uridine and cytidine by a partially purified preparation of uridine-cytidine kinase has been studied with dual-substrate kinetics. The kinetic patterns obtained are consistent with the theoretical analysis for two competing, alternate substrates interacting with a single enzyme. Thus, despite feedback regulation of the kinase by both UTP and CTP, the results allow a clear conclusion that both nucleosides are phosphorylated by the same enzyme, and probably at a single site, rather than by two closely related isozymes, each specific for one pyrimidine.
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