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  • Title: Synchronised transmembrane insertion and glycosylation of a nascent membrane protein.
    Author: Rothman JE, Lodish HF.
    Journal: Nature; 1977 Oct 27; 269(5631):775-80. PubMed ID: 200844.
    Abstract:
    Studies of the synthesis and incorporation of the vesicular stomatitis virus glycoprotein into membranes in a synchronised cell-free system demonstrate a tight coupling between polypeptide synthesis and membrane insertion, as a result of which the nascent chain crosses the membrane. The studies reveal a surprisingly precise sequence by which the nascent chain of this membrane glycoprotein is glycosylated in two steps. These findings have important implications for the mechanisms of membrane assembly.
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