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  • Title: [The effect of irradiation and alkylating agents on chromatin breakdown in normal and malignant lymphoid cells].
    Author: Riabchenko NI, Jurasková V, Ivannik BP, Konov AV, Drasil V.
    Journal: Radiobiologiia; 1991; 31(1):22-6. PubMed ID: 2008520.
    Abstract:
    Regularities of chromatin degradation in thymocytes and LS/BL tumor cells have been investigated. It has been shown that the rate of DNA degradation by Ca/Mg-dependent endonuclease in LS/BL tumor cells is 25 times lower than that in thymocytes, and radiation does not induce chromatin degradation. The alkylating agent TS 160 causes chromatin degradation in both LS/BL cells and thymocytes. In contrast to radiation TS 160 inhibits the endogenous chromatin degradation by Ca/Mg-dependent endonuclease in thymocytes.
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