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  • Title: [The effect of x-ray radiation and hypoxia on the proteolytic activity of the normal rat spleen and during tumor growth].
    Author: Likholat EA, Reva AD, Sokolov II, Chernaia VI.
    Journal: Radiobiologiia; 1991; 31(1):38-42. PubMed ID: 2008521.
    Abstract:
    The influence of X-radiation on activity of lysosomal enzymes (D, L, H cathepsins) in rat spleen tissue and in inoculated rat sarcoma 45 has been investigated. Intact rats and rats with tumors were subjected to whole-body and sarcoma 45 to local irradiation with doses of 0.155 C/kg and 0.31 C/kg in conditions of breathing gas hypoxic mixture containing 90% of nitrogen and 10% of oxygen (GHM-10). The combined exposure to radiation and GHM-10 was shown to produce a certain protective action (e.g. normalized cathepsin activity) in the spleen. In the tumor tissue the protective effect of GHM-10 was absent.
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