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  • Title: Enantioselective synthesis of substituted indanones from silyloxyallenes.
    Author: Brekan JA, Reynolds TE, Scheidt KA.
    Journal: J Am Chem Soc; 2010 Feb 10; 132(5):1472-3. PubMed ID: 20085317.
    Abstract:
    A new approach for the synthesis of enantioenriched indanones by asymmetric carbonyl-ene/intramolecular Heck cyclization from racemic silyloxyallenes has been developed. The modular procedure affords highly substituted indenes and indanones with excellent chirality transfer from the optically active carbinols. Full transfer of stereochemical information is achieved in the presence of 1,2,2,6,6-pentamethylpiperidine and PdCl(2)(PPh(3))(2) (1 mol %) in DMF under microwave heating. Short reaction times and high yields have been demonstrated on a variety of substrates.
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