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  • Title: Efficient synthesis of alpha-ketoamides via 2-acyl-5-aminooxazoles by reacting acyl chlorides and alpha-isocyanoacetamides.
    Author: Mossetti R, Pirali T, Tron GC, Zhu J.
    Journal: Org Lett; 2010 Feb 19; 12(4):820-3. PubMed ID: 20088495.
    Abstract:
    Acyl chlorides and alpha-isocyanoacetamides undergo an efficient reaction in dichloromethane in the presence of triethylamine to give 2-acyl-5-aminooxazoles. Subsequent acid hydrolysis of the 5-aminooxazole moiety leads to alpha-ketoamides in good overall yields.
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