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  • Title: Loss of membrane protein thiols and lipid peroxidation in allyl alcohol hepatotoxicity.
    Author: Pompella A, Romani A, Benedetti A, Comporti M.
    Journal: Biochem Pharmacol; 1991 Apr 15; 41(8):1255-9. PubMed ID: 2009100.
    Abstract:
    The data reported suggest that--following initiation of lipid peroxidation--membrane protein thiols can be attacked by lipid-derived radicals and/or reactive, lipid-soluble aldehydes like 4-hydroxynonenal and other hydroxyalkenals originated within the lipid core of cell membranes, resulting in a membrane protein thiol loss which is in turn associated with the development of hepatocellular injury.
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