These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Hexokinase bound to rat brain mitochondria uses externally added ATP more efficiently than internally generated ATP.
    Author: Kabir F, Nelson BD.
    Journal: Biochim Biophys Acta; 1991 Mar 01; 1057(1):147-50. PubMed ID: 2009276.
    Abstract:
    The rates of glucose phosphorylation by bound hexokinase were investigated in mitochondria isolated from rat brain. Initial rates obtained either with ATP generated from oxidative phosphorylation or with ATP added externally were compared. Our results show that the external ATP supports a 2-3-fold higher hexokinase activity than does ATP generated by oxidative phosphorylation under Stage 3 conditions. ATP formed by mitochondrial creatine kinase in the presence of creatine phosphate also supports higher initial rates of glucose phosphorylation than does oxidative phosphorylation. The data suggest that concentrations of ATP present in the cytosol of normal tissue will probably maintain higher rates of glucose phosphorylation than ATP being exported directly from the mitochondrial matrix at maximal State 3 rates.
    [Abstract] [Full Text] [Related] [New Search]