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  • Title: Potential therapeutic application of host defense peptides.
    Author: Zhang L, Falla TJ.
    Journal: Methods Mol Biol; 2010; 618():303-27. PubMed ID: 20094872.
    Abstract:
    Host defense peptides (HDPs) are relatively small, mostly cationic, amphipathic, and of variable length, sequence, and structure. The majority of these peptides exhibit broad-spectrum antimicrobial activity and often activity against viruses and some cancer cell lines. In addition, HDPs also provide a range of immunomodulatory activities related to innate immunity defense, inflammation, and wound healing. The development of these multi-faceted molecules and their bioactivities into clinically important therapeutics is being pursued using a number of different approaches. Here we review the role of HDPs in nature and application of this role to the development of novel therapeutics.
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