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  • Title: Synthesis and antimicrobial activity of novel pyrazolo[3,4-d]pyrimidin derivatives.
    Author: Khobragade CN, Bodade RG, Konda SG, Dawane BS, Manwar AV.
    Journal: Eur J Med Chem; 2010 Apr; 45(4):1635-8. PubMed ID: 20096486.
    Abstract:
    Pyrazolo[3,4-d]thiazolo[3,2-a]pyrimidin-4-one derivatives have been prepared by cyclocondensation of ethyl 2-cyano-3,3-bis(methylthio)prop-2-enoate with 2-amino-4-(substitutedphenyl)thiazole to give 3-cyano-2-methylthio-4-oxo-4H-6-(substitutedphenyl)thiazolo[3,2-a]pyrimidin (2a-j) and further reacting with hydrazine hydrate to yield the target compounds (3a-j). The chemical structure of the compounds was confirmed by IR and (1)H NMR spectral data. All the compounds of the series have been screened for their antibacterial and antifungal activity studies. The result revealed that all compounds showed significant antimicrobial activity.
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