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  • Title: Genomic characterization of a novel human papillomavirus (HPV-117) with a high viral load in a persisting wart.
    Author: Köhler A, Gottschling M, Förster J, Röwert-Huber J, Stockfleth E, Nindl I.
    Journal: Virology; 2010 Mar 30; 399(1):129-133. PubMed ID: 20096912.
    Abstract:
    Warts from immunosuppressed organ transplant recipients (OTR) persist over years and may progress into non-melanoma skin cancer. Human papillomaviruses (HPV) are considered the causal agents for the development of such warts. We isolated the novel type HPV-117 from a persisting wart by rolling circle amplification. One hundred eighteen warts from immunocompetent patients (IC) and 49 warts from OTR were analyzed by HPV-117 E6 type-specific PCR. As inferred from a phylogenetic analysis, the new type HPV-117 belonged to alpha-PV species 2, including the most similar types HPV-10 and HPV-94. The general prevalence of HPV-117 in warts was 2% in IC (2/118), and 12% in OTR (6/49). The high viral load in dysplastic cells of a Verruca vulgaris was shown by in situ hybridization. Our results suggest an active role of the novel type in the development of cutaneous warts of OTR.
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