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  • Title: Clozapine therapy raises serum concentrations of high sensitive C-reactive protein in schizophrenic patients.
    Author: Löffler S, Löffler-Ensgraber M, Fehsel K, Klimke A.
    Journal: Int Clin Psychopharmacol; 2010 Mar; 25(2):101-6. PubMed ID: 20101184.
    Abstract:
    Eight schizophrenic inpatients without manifest comorbidity were longitudinally studied. The aim was to find whether clozapine, the prototype of atypical antipsychotic drugs, altered their serum concentrations of high sensitive C-reactive protein (hsCRP), an inflammatory marker of high clinical importance. Following first-time therapy with clozapine, predominantly as the sole antipsychotic for 8 weeks, hsCRP profiles increased subclinically by 600%. This rise, and the Spearman correlation between hsCRP values and corresponding leukocyte counts, was statistically significant. A one-time cross-section investigation of 25 long-term clozapine patients and 25 patient controls did not show an elevation of hsCRP under clozapine after 1 year and more. It is assumed that the clozapine-evoked increase of hsCRP is part of a transient acute-phase response. The underlying inflammatory process needs clarification.
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