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  • Title: Blumeaenes A-J, sesquiterpenoid esters from Blumea balsamifera with NO inhibitory activity.
    Author: Chen M, Qin JJ, Fu JJ, Hu XJ, Liu XH, Zhang WD, Jin HZ.
    Journal: Planta Med; 2010 Jun; 76(9):897-902. PubMed ID: 20101563.
    Abstract:
    Chemical examination of the ethanol extract of the aerial parts of Blumea balsamifera led to the isolation of ten new sesquiterpenoid esters, blumeaenes A-J (1- 10), with 13 known flavonoids. Their structures were determined mainly by use of 1D and 2D NMR spectroscopic techniques. All sesquiterpenoid esters were tested for their inhibitory activity against LPS-induced NO production in RAW264.7 macrophages. Compounds 1, 4 and 5 showed slight inhibitory effect on the production of NO with IC(50) values of 40.06, 46.35 and 57.80 microg/mL, respectively.
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