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  • Title: Actiketal, a new member of the glutarimide antibiotics.
    Author: Sonoda T, Osada H, Uzawa J, Isono K.
    Journal: J Antibiot (Tokyo); 1991 Feb; 44(2):160-3. PubMed ID: 2010356.
    Abstract:
    A new glutarimide antibiotic named actiketal was isolated from the culture fluid of the epiderstatin-producing streptomycete, Streptomyces pulveraceus subsp. epiderstagenes. The IC50 of the antibiotic for inhibition of the incorporation of [3H]thymidine into epidermal growth factor-stimulated Balb/MK cells was 14.5 microM. The structure of this compound was determined by 1H and 13C NMR spectroscopic analyses using 1H-1H COSY, 13C-1H COSY, heteronuclear multiple-bond correlation spectroscopy, selective 13C-[1H] NOE's techniques.
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