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  • Title: Direct asymmetric allylic alkylation of butenolides with Morita-Baylis-Hillman carbonates.
    Author: Cui HL, Huang JR, Lei J, Wang ZF, Chen S, Wu L, Chen YC.
    Journal: Org Lett; 2010 Feb 19; 12(4):720-3. PubMed ID: 20104883.
    Abstract:
    The direct asymmetric allylic alkylation of beta,gamma-butenolides with MBH carbonates to access gamma,gamma-disubstituted butenolides containing adjacent quaternary and tertiary chiral centers has been presented in excellent stereoselectivities (86-96% ee, dr >95:5) and moderate to good yield (50-83%). Their synthetic utility has been well demonstrated by the facile construction of bicyclic lactones bearing 4-5 stereogenic centers.
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