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  • Title: Myeloma cells with asurophilic granules--an unusual morphological variant--case presentation.
    Author: Vlădăreanu AM, Cîşleanu D, Derveşteanu M, Onisâi M, Bumbea H, Radeşi S, Begu M, Cristina B.
    Journal: J Med Life; 2008; 1(1):74-86. PubMed ID: 20108484.
    Abstract:
    We present the case of an 80-year-old man who was admitted for anemia, back pain and progressive weakness. After a workup of clinical and laboratory data, the final diagnosis was multiple myeloma. The bone marrow aspirate revealed 53% myeloma cells with peculiar and rare morphological features: numerous large asurophilic--bright red granules--mucopolizaccharides and immunoglobulins secreted and accumulated in the endoplasmic reticulum, typically known as Russel bodies.
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