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  • Title: Rosai-Dorfman disease of the nasal cavities: A CO(2) laser excision.
    Author: Belcadhi M, Bellakhdhar M, Sriha B, Bouzouita K.
    Journal: Am J Rhinol Allergy; 2010; 24(1):91-3. PubMed ID: 20109334.
    Abstract:
    BACKGROUND: Rosai-Dorfman disease (RDD) is a rare nonneoplastic histiocytic proliferative disorder characterized by painless massive lymphadenopathy. Extranodal manifestations frequently occur in the head and neck area. METHODS: We report the clinical and histological features of nasal cavities and cervical lymph node RDD in a 72-year-old woman, who complained of major nasal obstruction and hyposmia. RESULTS: Nasal endoscopy revealed polypoid masses arising from the turbinates; the septum was intact. Immunohistochemical analysis revealed staining for S-100 protein, CD68, and alpha-1 antitrypsin. The presence of the Epstein-Barr virus was revealed by serology and also by in situ hybridization. The general examination and systemic evaluation did not find other extranodal localization. CONCLUSION: Because the disease is known for not responding to local or systemic steroids, CO(2) laser excision was used to clear the nasal obstruction with a satisfactory result. This is, to the best of our knowledge, the first description of the use of laser excision for nasal cavities RDD.
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