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  • Title: In vitro characterization of two types of LDL apheresis module and effect of repetitive LDL apheresis on plasma cholesterol levels and aortic atherosclerosis in heterozygous WHHL rabbits.
    Author: Kim SS, Kutsumi Y, Nakai T, Miyabo S.
    Journal: Jpn Circ J; 1991 Jan; 55(1):68-80. PubMed ID: 2010950.
    Abstract:
    In vitro filtration was used to characterize and compare the function of two types of LDL apheresis module: membrane filtration (module M: pore diameter, 0.04 micron; effective surface area, 0.1 m2) and LDL adsorption (module A: a column containing 20 ml of polyvinyl alcohol gels fixed with polyacrylic acid). Module A had better selectivity of LDL removal, while module M could rapidly remove a larger amount of LDL. The effect of repetitive LDL apheresis with module A on the plasma cholesterol level and on the development of aortic atherosclerosis was examined in 6 heterozygous WHHL rabbits (5 to 10 months old; mean plasma total cholesterol level, 270 +/- 39 mg/dl), treated with LDL apheresis at weekly intervals for 2 months. Plasma total and LDL cholesterols were lowered approximately 40% by a signal procedure. The LDL cholesterol level tended to decrease as treatment progressed, while the HDL cholesterol level was unchanged or rose above the baseline value in a week after LDL apheresis. The ratio of atherosclerotic lesion area to whole aortic area was relatively low in treated rabbits (6.5 +/- 1.9%) in comparison with that in 5 untreated heterozygous WHHL rabbits (18.3 +/- 7.7%). The mean cholesterol content in the thoracic aorta was 4.9 +/- 1.3 mg/g wet tissue in treated rabbits vs 13.3 +/- 6.1 mg/g wet tissue in untreated rabbits. These results suggest that repetitive LDL apheresis might be effective in maintaining a lower level of LDL cholesterol and retarding the atherosclerotic process in vivo.
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