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  • Title: Effect of long-term L-dopa administration on striatal extracellular dopamine release.
    Author: Brannan T, Martinez-Tica J, Yahr MD.
    Journal: Neurology; 1991 Apr; 41(4):596-8. PubMed ID: 2011263.
    Abstract:
    When L-dopa was administered acutely to rats, the increase in the extracellular level of dopamine in the corpus striatum was attenuated by 43% in animals that had received L-dopa daily for 60 days as compared with animals receiving placebo. These findings indicate that chronic treatment with L-dopa impairs striatal dopamine formation or release.
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