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  • Title: Note: Interference technique for minimally invasive, subnanometer, microsecond measurements of displacements.
    Author: Dujovne I, Kerssemakers J, Cappello G, Dekker C.
    Journal: Rev Sci Instrum; 2010 Jan; 81(1):016103. PubMed ID: 20113134.
    Abstract:
    We present a novel high-resolution technique for single-molecule experiments, viz., differential traveling wave tracking. This is an interference-based scattering technique where we use gold nanoparticles for high scattering intensities and incorporate differential measurements along one in-plane direction to subtract mechanical noise and drift of the system. In addition, out-of-plane distances are measured via scattered light intensity in a total internal reflectance illumination field. In plane, we demonstrate a rms noise level of only 0.10 nm at 10 kHz and less than 0.5 nm at 600 kHz.
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