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  • Title: Different cross-reactivity of human and rodent sera to Tula virus and Puumala virus.
    Author: Tegshduuren E, Yoshimatsu K, Taruishi M, Endo R, Shimizu K, Koma T, Yasuda SP, Kariwa H, Arikawa J, Ishihara C.
    Journal: Comp Immunol Microbiol Infect Dis; 2010 Dec; 33(6):e67-73. PubMed ID: 20116854.
    Abstract:
    Tula virus (TULV) and Puumala virus (PUUV) are hantaviruses carried by the bank vole (Myodes glareolus) and European common vole (Microtus arvalis), respectively. PUUV is a causative agent of hemorrhagic fever with renal syndrome (HFRS), while TULV is thought to be apathogenic to humans. The N-terminal regions of the N proteins from TULV and PUUV were expressed and applied as enzyme-linked immunosorbent assay (ELISA) antigens. Colonized Japanese grass voles (Microtus montebelli) and BALB/c mice were used for experimental inoculation of the vole-borne hantaviruses TULV and PUUV. Voles and mice showed significant antibody production toward both viruses, but these antisera showed little cross-reactivity between TULV and PUUV in the immunofluorescence antibody assay and ELISA. In contrast, sera from patients with HFRS caused by PUUV exhibited high cross-reactivity against the TULV antigen, and sera from a natural rodent reservoir showed moderate cross-reactivity against the heterologous antigen, indicating that the antigenic cross-reactivity between TULV and PUUV differs in sera from rodents and humans.
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