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  • Title: Relative bioavailability of the flavonoids quercetin, hesperetin and naringenin given simultaneously through diet.
    Author: Krogholm KS, Bredsdorff L, Knuthsen P, Haraldsdóttir J, Rasmussen SE.
    Journal: Eur J Clin Nutr; 2010 Apr; 64(4):432-5. PubMed ID: 20125185.
    Abstract:
    The bioavailability and urinary excretion of three dietary flavonoids, quercetin, hesperetin and naringenin, were investigated. Ten healthy men were asked to consume a 'juice mix' containing equal amounts of the three flavonoids, and their urine and plasma samples were collected. The resulting mean plasma area under the curve (AUC)(0-48 h) and C(max) values for quercetin and hesperetin were similar, whereas the AUC(0-48 h) of naringenin and, thus, the relative bioavailability were higher after consumption of the same dose. The study consolidates a significantly lower urinary excretion of quercetin (1.5+/-1%) compared with hesperetin (14.2+/-9.1%) and naringenin (22.6+/-11.5%) and shows that this is not due to a lower bioavailability of quercetin, but rather reflects different clearance mechanisms.
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