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  • Title: Modified cyclic nucleotide systems in Morris hepatoma 3924A favoring expression of cyclic GMP effect.
    Author: Shoji M, Morris HP, Davis CW, Brackett NL, Kuo JF.
    Journal: Biochim Biophys Acta; 1977 Dec 22; 500(2):419-24. PubMed ID: 201299.
    Abstract:
    Modifications in the cyclic nucleotide systems favoring the expression of cyclic GMP effects were found to occur in the transplanted fast-growing Morris hepatoma 3924A. These included: (a) a decreased level of cyclic GMP phosphodiesterase and an increased level of cyclic AMP phosphodiesterase; (b) a disproportionately increased level of cylic GMP-dependent protein kinase relative to that of cyclic AMP-dependent protein kinase; (c) a disproportionately increased level of stimulatory modulator of cyclic AMP-dependent protein kinase relative to that of inhibitory modulator of cyclic AMP-dependent protein kinase; and (d) an increased level of phosphoprotein phosphatase.
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