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  • Title: Cranial nerve palsy in childhood acute lymphoblastic leukemia and non-Hodgkin's lymphoma.
    Author: Ingram LC, Fairclough DL, Furman WL, Sandlund JT, Kun LE, Rivera GK, Pui CH.
    Journal: Cancer; 1991 May 01; 67(9):2262-8. PubMed ID: 2013032.
    Abstract:
    Forty-five children with acute lymphoblastic leukemia or non-Hodgkin's lymphoma had cranial nerve palsy (CNP) as a complication of their disease. Twenty-two of these children had CNP initially and 23, at relapse, with or without previous hematologic relapse. Only one of the 23 patients with CNP at relapse was a long-term survivor. In contrast, 11 of the 22 children who had CNP initially survived in remission for 3+ months to 13+ years. Two factors are associated with an improved outcome for patients with CNP at diagnosis: treatment after 1979 (P less than 0.004) and male gender (P less than 0.01). Patients who received radiation therapy fared better than those for whom radiation was not given (disease-free survival at 2 years 53% versus 29%). The authors conclude that CNP signifies an aggressive or advanced disease requiring intensive systemic chemotherapy and that the role of irradiation should be examined for this group of patients.
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