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  • Title: Domino Heck-aza-Michael reactions: efficient access to 1-substituted tetrahydro-beta-carbolines.
    Author: Priebbenow DL, Henderson LC, Pfeffer FM, Stewart SG.
    Journal: J Org Chem; 2010 Mar 05; 75(5):1787-90. PubMed ID: 20131765.
    Abstract:
    A simple and efficient palladium-catalyzed domino reaction for the synthesis of a series of C1-substituted tetrahydro-beta-carbolines is described. This domino process involves a Heck reaction at the indole 2-position of a halogenated tryptamine precursor, followed by intramolecular aza-Michael addition.
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