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  • Title: In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives.
    Author: Achar KC, Hosamani KM, Seetharamareddy HR.
    Journal: Eur J Med Chem; 2010 May; 45(5):2048-54. PubMed ID: 20133024.
    Abstract:
    A series of 2-methylaminobenzimidazole derivatives (1-11) were synthesized by the reaction of 2-(chloromethyl)-1H-benzimidazole derivatives with primary aromatic amines. All these compounds were characterized by IR, 1H NMR, 13C NMR, GC-MS and elemental analysis. The newly synthesized compounds were screened for analgesic and anti-inflammatory activities on acetic acid induced writhing in mice and carrageenan induced paw oedema in rats. Compounds (7) and (2) showed a potent analgesic (89% at 100 mg/kg b.w) and anti-inflammatory (100% at 100 mg/kg b.w) activities compared with standard drug Nimesulide (100% at 50 mg/kg b.w) respectively. The other compounds showed good analgesic and anti-inflammatory activities.
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