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  • Title: Assessing the relationship between compliance with antidepressant therapy and employer costs among employees in the United States.
    Author: Birnbaum HG, Ben-Hamadi R, Kelley D, Hsieh M, Seal B, Kantor E, Cremieux PY, Greenberg PE.
    Journal: J Occup Environ Med; 2010 Feb; 52(2):115-24. PubMed ID: 20134337.
    Abstract:
    OBJECTIVE: To assess effects of antidepressant treatment compliance on health care and workplace costs. METHODS: By using workplace survey data linked to two employers' health care claims, employees with depression/antidepressant claims were categorized into noncompliant/compliant groups. Annualized costs were compared between compliance groups, for the employees with antidepressant use and a subset diagnosed with depression. RESULTS: Among antidepressant users (N = 1224), medical costs were not statistically different for compliant versus noncompliant patients; drug costs were higher for compliant patients, primarily because of antidepressants' costs. Similar associations were observed among depressed patients (N = 488). Absenteeism costs were lower for compliant patients with antidepressant use ($3857 vs $4,907, P = 0.041) and among depressed patients ($3976 vs $5899, P = 0.047). Presenteeism costs were higher for depressed compliant patients ($19,170 vs $15,829, P = 0.011). CONCLUSIONS: Increased compliance with antidepressants is significantly associated with reduced absenteeism costs.
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