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  • Title: Paxillin expression levels are correlated with clinical stage and metastasis in salivary adenoid cystic carcinoma.
    Author: Shi J, Wang S, Zhao E, Shi L, Xu X, Fang M.
    Journal: J Oral Pathol Med; 2010 Aug 01; 39(7):548-51. PubMed ID: 20136697.
    Abstract:
    AIMS: To investigate the relationship between paxillin expression and clinicopathological features and metastasis in salivary adenoid cystic carcinoma (SACC). METHODS: A total of 47 SACC were assessed histochemically for paxillin expression. Paxillin immunoreactivity was compared with histological type, clinical stage and distant metastasis. RESULTS: Paxillin expression was identified in 57.45% of SACC as cytoplasmic staining and the expression was correlated with distant metastasis and clinical stage (P < 0.05), but not with histological type. CONCLUSIONS: Our observations indicate that paxillin expression is upregulated in SACC. High expression of paxillin was correlated with a more advanced stage and metastasis in SACC, suggesting that paxillin is a disease marker in advanced SACC and SACC with distant metastasis, and, consequently, may have value as a therapeutic target for SACC.
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