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  • Title: Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A(2B) adenosine receptor antagonists.
    Author: Eastwood P, Gonzalez J, Paredes S, Nueda A, Domenech T, Alberti J, Vidal B.
    Journal: Bioorg Med Chem Lett; 2010 Mar 01; 20(5):1697-700. PubMed ID: 20137946.
    Abstract:
    The synthesis and SAR of a series of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent A(2B) adenosine receptor antagonists is described. Several compounds showed good selectivity versus other adenosine receptors. The potent and selective analogue 9 was shown to have good oral bioavailability in the rat.
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