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  • Title: Epstein-Barr virus mimicking lymphoma on FDG-PET/CT.
    Author: Thomas DL, Syrbu S, Graham MM.
    Journal: Clin Nucl Med; 2009 Dec; 34(12):891-3. PubMed ID: 20139824.
    Abstract:
    We report the case of a 17-year-old girl who presented with a several month history of fevers and abdominal pain. After cytomegalovirus (CMV) and Epstein-Barr virus (EBV) titers returned normal, FDG-PET/CT was obtained due to concern for lymphoma. FDG-PET/CT revealed a pattern of hypermetabolic activity in the adenoids, bilateral cervical lymph nodes, abdominal lymph nodes, and spleen, highly concerning for lymphoma. However, subsequent biopsy of a cervical lymph node revealed lymphadenitis consistent with EBV. This case highlights infection as the most well-known false-positive cause on FDG-PET, and how biopsy is essential to definitively distinguish malignancy from infection.
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