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  • Title: "Click" grafting of high loading of polymers and monosaccharides on surface of ordered mesoporous silica.
    Author: Huang L, Dolai S, Raja K, Kruk M.
    Journal: Langmuir; 2010 Feb 16; 26(4):2688-93. PubMed ID: 20141209.
    Abstract:
    The azide-alkyne cycloaddition "click" reaction was used to covalently bond high loadings of polymers and monosaccharides to the surface of an ordered mesoporous silica. The functionalization process was followed using thermogravimetry, gas adsorption, small-angle X-ray scattering, and infrared spectroscopy. Large-pore SBA-15 silica with cylindrical mesopores of diameter approximately 15 nm was synthesized using triisopropylbenzene as a micelle expander. The surface of the silica was modified with aminopropyl groups that were converted to propargyl-bearing groups through a reaction with 4-pentynoyl chloride. Thus prepared "clickable" pores were reacted with azide-functionalized poly(methyl methacrylate) (PMMA) and oligo(ethylene glycol) as well as protected and deprotected D-galactose. The new "grafting to" procedure allowed us to introduce uniform polymer films of thickness up to about 2 nm without any appreciable pore blocking, even for the polymer loading as high as 25 wt %. Uniform layers of monosaccharides with loadings up to 20 wt % were also obtained with remarkable grafting efficiency. No change in the periodic structure of the silica support was observed throughout the grafting process. These results demonstrate that the "click" reaction is a powerful approach to ordered mesoporous silicas with accessible pores functionalized with high loadings of various macromolecules and biomolecules.
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