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  • Title: Chemical constituents from the leaves and stems of Schisandra rubriflora.
    Author: Xiao WL, Yang SY, Yang LM, Yang GY, Wang RR, Zhang HB, Zhao W, Pu JX, Lu Y, Zheng YT, Sun HD.
    Journal: J Nat Prod; 2010 Feb 26; 73(2):221-5. PubMed ID: 20146529.
    Abstract:
    Six new nortriterpenoids, schirubridilactones A-F (1-6), as well as 14 known compounds, were isolated from the leaves and stems of Schisandra rubriflora. The structures of 1-6 were elucidated on the basis of spectroscopic methods including HSQC, HMBC, (1)H-(1)H COSY, and ROESY NMR experiments. The relative stereochemistry of 1 was confirmed through single-crystal X-ray analysis. In addition, compounds 1-6 showed anti-HIV-1 activity with EC(50) values in the range 14.3-80.8 microg/mL and selectivity indices in the range 2.2-9.0.
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