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  • Title: Serum hepatitis B virus DNA in hepatitis B virus seropositive and seronegative patients with normal liver function.
    Author: Pao CC, Yao DS, Lin CY, Kao SM, Tsao KC, Sun CF, Liaw YF.
    Journal: Am J Clin Pathol; 1991 Apr; 95(4):591-6. PubMed ID: 2014786.
    Abstract:
    The presence of hepatitis type B virus (HBV) DNA in serum specimens from 926 apparently healthy people with normal liver functions was determined by polymerase chain reaction; 41.2% of people with positive results for HBV surface antigen (HBsAg) (94 of 228) and 95.2% of people with positive results for HBV e antigen (HBeAg) (60 of 63) were found to have positive results for serum HBV DNA. On the other hand, serum HBV DNA was found in 11.0% (77 of 698) of HBsAg-negative people and in 13% (69 of 530) of those who had positive results for serum antibodies directed against HBsAg. The results seem to suggest that HBV DNA can be found in a significant portion of apparently healthy people with normal liver function who are either seronegative for HBsAg or seropositive for antibodies directed against HBsAg.
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