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  • Title: Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [Tc] TRODAT-1.
    Author: Chang TT, Yeh TL, Chiu NT, Chen PS, Huang HY, Yang YK, Lee IH, Lu RB.
    Journal: Bipolar Disord; 2010 Feb; 12(1):102-6. PubMed ID: 20148872.
    Abstract:
    OBJECTIVES: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients. METHODS: Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1. RESULTS: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT. CONCLUSIONS: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.
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