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  • Title: Epidural infusion of diamorphine with bupivacaine in labour. A comparison with fentanyl and bupivacaine.
    Author: Enever GR, Noble HA, Kolditz D, Valentine S, Thomas TA.
    Journal: Anaesthesia; 1991 Mar; 46(3):169-73. PubMed ID: 2014889.
    Abstract:
    We have compared the analgesic effects of three epidural infusions in a randomised, double-blind study of 61 mothers in labour. An initial dose of bupivacaine 0.5% 8 ml was followed by either bupivacaine 0.125%, bupivacaine 0.125% with diamorphine 0.0025% or bupivacaine 0.125% with fentanyl 0.0002%. All infusions were run at a rate of 7.5 ml/hour. Analgesia was significantly better in both the groups receiving opioids. Diamorphine was shown to be the more effective supplement to bupivacaine. The 5% incidence of pruritus in the opioid groups was less than that reported by earlier authors.
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